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KMID : 0043320080310050617
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Archives of Pharmacal Research
2008 Volume.31 No. 5 p.617 ~ p.621
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5-Methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)-psoralen Isolated from Angelica dahurica Inhibits Cyclooxygenase-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells
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Hua Jin-Mei
Moon Tae-Chul
Hong Tae-Gyun
Park Kyong-Min
Son Jong-Keun
Chang Hyun-Wook
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Abstract
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5-Methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)-psoralen (MP) is a medicinal herbal product isolated from Angelica dahurica that inhibits the cyclooxygenase-2 (COX-2)-dependent phase of prostaglandin generation in bone marrow-derived mast cells (, ). Western blotting with specific anti-COX-2 antibodies showed that the decrease in production was accompanied by a decrease in COX-2 protein levels. In addition, this compound consistently inhibited the production of leukotriene in a dose dependent manner, (, ). These results demonstrate that MP inhibits both cyclooxygenase-2 and 5- lipoxygenase activity. Furthermore, this compound also inhibited the degranulation reaction , ). Therefore, this compound might provide a basis for novel anti-inflammatory drug development.
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KEYWORD
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Angelica dahurica, Cyclooxygenase-2, 5-Lipoxygenase, Bone marrow-derived mast cells, Inflammation
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